The Baltimore Orioles make the short trip up I-95 to face the Boston Red Sox on Wednesday, July 22, 2026, with first pitch scheduled for 7:10 PM ET at Fenway Park. Kyle Bradish gets the ball for Baltimore in what shapes up as a meaningful mid-summer AL East showdown. The Red Sox have not announced a probable starter. Fans can catch the game on MASN or listen on WBAL 1090 AM. With division standings always in play this time of year, every game at Fenway carries weight for a Baltimore club that takes the rivalry with Boston seriously.

Kyle Bradish Takes the Mound for Baltimore

Bradish is the story on this side of the equation. The right-hander has been one of the more important arms in Baltimore's rotation, and his performance Wednesday will set the tone for however long the Orioles stay in this one. Without a confirmed Red Sox starter, Bradish enters with a clear opportunity to dictate the pace of the game early. How deep he goes and how efficiently he works through a Boston lineup that can turn a lineup card over will be the central question of the night.

Baltimore Lineup Features Henderson, Alonso, and O'Neill

Manager Brandon Hyde has constructed a lineup with real pop from top to bottom. Gunnar Henderson slots in at third in the order at shortstop, with Pete Alonso hitting second at first base. Tyler O'Neill comes in fourth at right field, giving Baltimore a legitimate middle-of-the-order threat against whatever Boston sends to the mound. Taylor Ward leads things off in left, and Christian Encarnacion-Strand bats fifth at third base. Dylan Beavers hits sixth in center, Johnathan Rodríguez slots in seventh as the DH, Jackson Holliday bats eighth at second base, and Chadwick Tromp rounds out the order at catcher.

Boston Lineup Presents Real Challenges for Bradish

The Red Sox counter with a lineup that demands attention. Ceddanne Rafaela hits second in center and Wilyer Abreu bats third in right, with Willson Contreras anchoring cleanup at first base. Masataka Yoshida hits fifth as the DH. Jarren Duran drops to seventh in left field. Anthony Seigler leads off at second base, and Carlos Narváez catches in the nine hole. Bradish will need to be sharp against this group, particularly through the middle of the order where Boston can do real damage.

Keys to Watch Wednesday Night

• How long Bradish lasts and whether he can limit the Red Sox's middle-of-the-order threats in Contreras and Yoshida
• Whether Gunnar Henderson and Pete Alonso can generate offense against an unannounced Boston starter
• Jackson Holliday's at-bats from the eight hole — his ability to get on base in front of Tromp keeps pressure on Boston pitching
• Fenway Park's short left-field wall is always a factor; Bradish's ability to suppress fly balls to left will matter
• Dylan Beavers and Johnathan Rodríguez providing production from the lower half of Baltimore's lineup

Prediction

Fenway is never an easy venue, and without knowing who Boston is sending to the mound, there's genuine uncertainty on that side of the equation. What Baltimore does control is Bradish, and if he delivers a quality start — six-plus innings, three runs or fewer — this Orioles lineup has enough firepower with Henderson, Alonso, and O'Neill to win a game on the road. Expect a competitive game that comes down to late innings. Orioles 5, Red Sox 3.